کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3062102 | 1187485 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phosphatidylinositol 3-kinase activity is required for the induction of differentiation in C6 glioma cells by panaxydol
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
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چکیده انگلیسی
Panaxydol isolated from the lipophilic fractions of Tienchi ginseng (Panax notoginseng) induces growth inhibition and differentiation of rat C6 glioma cells. The underlying molecular mechanisms are not completely understood. In the present study, we identified phosphatidylinositol 3-kinase (PI 3-K) as a necessary enzyme for the differentiation of C6 cells treated with panaxydol. The specific PI 3-K inhibitor wortmannin resulted in attenuated differentiation of C6 cells induced by panaxydol, and was associated with perinuclear localization of glial fibrillary acidic protein expression and a diminished process formation. These data suggest that induction of differentiation in C6 cells by panaxydol could be mediated through a PI 3-K-dependent pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 16, Issue 3, March 2009, Pages 444-448
Journal: Journal of Clinical Neuroscience - Volume 16, Issue 3, March 2009, Pages 444-448
نویسندگان
Jian Hai, Qi Lin, Yang Lu,