کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3062624 1187494 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Risk factors in development of motor complications in Chinese patients with idiopathic Parkinson’s disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Risk factors in development of motor complications in Chinese patients with idiopathic Parkinson’s disease
چکیده انگلیسی

Motor complications induced by levodopa (L-dopa) treatment in Parkinson’s disease (PD) are not well documented in patients of Chinese ethnicity. We performed a cross-sectional study to investigate the prevalence of dyskinesias and motor fluctuations, and the factors determining their development, in a population of Chinese patients with PD. Among 137 patients with PD, 98 (71.5%) had received a L-dopa preparation. Motor fluctuations were found in 74.5% and dyskinesias in 77.6% of the 98 patients. Patients with dyskinesias were younger at onset of disease than those without. Patients with dyskinesias and motor fluctuations had significantly longer duration of PD and L-dopa treatment, higher daily doses of L-dopa, and higher scores in the 39-item Parkinson’s Disease Questionnaire (PDQ-39), when compared to patients without motor complications. Among these factors, motor fluctuations were best predicted by duration of L-dopa treatment and dyskinesias by disease duration. We conclude that motor complications are closely related to disease and treatment parameters, especially the treatment and disease duration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 16, Issue 8, August 2009, Pages 1034–1037
نویسندگان
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