کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3062662 | 1187495 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Integrins: Molecular determinants of glioma invasion
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
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چکیده انگلیسی
Gliomas, the most common form of brain tumour are characterised by a capacity to invade throughout normal brain tissue. This infiltrative nature is the hallmark of poor prognosis. A greater understanding of the molecular determinants that drive invasion may lead to improved therapy. Integrins are a large family of cell surface receptors that mediate interaction between a cell and the extracellular matrix. Integrins facilitate extracellular matrix dependent organization of the cytoskeleton and activation of intracellular signalling that is required for the regulation of cell adhesion and migration. Since integrins are key regulators of these processes, the role these receptors play in tumour invasion is a field of intense research.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 14, Issue 11, November 2007, Pages 1041–1048
Journal: Journal of Clinical Neuroscience - Volume 14, Issue 11, November 2007, Pages 1041–1048
نویسندگان
Giovanna M. D’Abaco, Andrew H. Kaye,