کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3063584 1187522 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Motor cortex reorganisation in Parkinson’s disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Motor cortex reorganisation in Parkinson’s disease
چکیده انگلیسی

Transcranial magnetic stimulation mapping of the motor cortical projection to the hand was performed in a group of patients with Parkinson’s disease (PD) of variable duration to determine whether there is evidence of cortical reorganisation. Map shifts were found in the majority of PD cases (12/15), in untreated early cases as well as treated cases of longer duration, and there was a correlation between inter-side difference in the severity of PD symptoms (Unified Parkinson’s Disease Rating Scale) and interhemispheric map displacement (r = 0.60; P = 0.018). These findings indicate that there is reorganisation of the corticomotor representation of the hand in PD, even at a relatively early stage of the disease, and suggest a dynamic process of reorganisation in the motor cortex due to an increase in the pallidal inhibitory inputs to the thalamo-cortical projections.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 13, Issue 6, July 2006, Pages 639–642
نویسندگان
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