کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3075077 1580960 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of regional gray matter volumes in the brain with disruptive behavior disorders in male and female children
ترجمه فارسی عنوان
انجمن میزان حجم خاکستری منطقه ای در مغز با اختلالات رفتاری در کودکان و نوجوانان
کلمات کلیدی
اختلال عملکرد دوران کودکی، مورفومتری مبتنی بر وکسل، ماده خاکستری، سوزن طولانی بالا
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• Did not replicate some findings on reduced gray matter and conduct disorder
• Found a nonlinear association of CD severity with reduced temporal gray matter
• Findings were stronger in girls, consistent with the differential threshold model.

Because the disruptive behavior disorders are highly impairing conditions, it is important to determine if structural variations in brain are associated early in life with these problems among children.Structural MRI data were acquired from 111 9–11 year olds (58 girls and 53 boys), 43 who met diagnostic criteria for oppositional defiant disorder and/or conduct disorder and 68 healthy controls. Voxel-based morphometry was used to examine associations of behavioral measures with gray matter volumes in whole-brain analyses.Unlike previous studies, variation in gray matter volume was not found to be associated with a disruptive behavior disorder diagnosis in any brain region at p < .05 with FWE correction. Nonetheless, an inverse nonlinear association of the number of conduct disorder (CD) symptoms with gray matter volume along the left superior temporal sulcus was significant in the full sample (p < .05 with FWE correction), with a trend in the right hemisphere (p < 0.001 uncorrected). There also was a trend toward a stronger association of the number of CD symptoms with gray matter volume along the left superior temporal sulcus in girls than boys.The present findings did not replicate previous findings of reduced gray matter volumes in the anterior insula, amygdala, and frontal cortex in youth with CD, but are consistent with previous findings of reduced gray matter volumes in temporal regions, particularly in girls.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 7, 2015, Pages 252–257
نویسندگان
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