کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3075179 1580958 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of rhythmic stimulus presentation on oscillatory brain activity: the physiology of cueing in Parkinson’s disease
ترجمه فارسی عنوان
اثرات ارائه محرک های ریتمیک بر فعالیت مغز نوظهور: فیزیولوژی سیکلینگ در بیماری پارکینسون
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• We investigate how rhythmic cues improve movement in Parkinson’s disease
• MEG-recorded slow and fast oscillatory activity was analysed
• Predictive modulation of beta oscillations was reduced in PD patients
• Yet rhythmicity promoted a predictive mode of cue utilization and beta modulation
• Results point to a facilitation of basal ganglia-cortical interaction in rhythmic cueing

The basal ganglia play an important role in beat perception and patients with Parkinson’s disease (PD) are impaired in perception of beat-based rhythms. Rhythmic cues are nonetheless beneficial in gait rehabilitation, raising the question how rhythm improves movement in PD. We addressed this question with magnetoencephalography recordings during a choice response task with rhythmic and non-rhythmic modes of stimulus presentation. Analyses focused on (i) entrainment of slow oscillations, (ii) the depth of beta power modulation, and (iii) whether a gain in modulation depth of beta power, due to rhythmicity, is of predictive or reactive nature. The results show weaker phase synchronisation of slow oscillations and a relative shift from predictive to reactive movement-related beta suppression in PD. Nonetheless, rhythmic stimulus presentation increased beta modulation depth to the same extent in patients and controls. Critically, this gain selectively increased the predictive and not reactive movement-related beta power suppression. Operation of a predictive mechanism, induced by rhythmic stimulation, was corroborated by a sensory gating effect in the sensorimotor cortex. The predictive mode of cue utilisation points to facilitation of basal ganglia-premotor interactions, contrasting with the popular view that rhythmic stimulation confers a special advantage in PD, based on recruitment of alternative pathways.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 9, 2015, Pages 300–309
نویسندگان
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