Neural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit hyperactivity disorder

• 22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.
• First study directly comparing neural function in 22q11DS vs. ADHD patients
• 22q11DS and ADHD patients show a shared deficit in RI-related activation.
• ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.
• Neural activity is inversely correlated with self-reported Cognitive Impulsivity in 22q11DS.