کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3075185 | 1580958 | 2015 | 9 صفحه PDF | دانلود رایگان |
• We recorded resting-state magnetoencephalography in school-age children born very preterm and healthy children.
• We examine functional connectivity across a wide frequency spectrum in brain space.
• Global reductions in neural synchrony were detected in children born very preterm.
• These reductions encompass networks related to executive function and overall cognitive flexibility.
• These effects may be relevant to cognitive and behavioural difficulties reported in the ex-preterm population.
Many children born very preterm (≤32 weeks) experience significant cognitive difficulties, but the biological basis of such problems has not yet been determined. Functional MRI studies have implicated altered functional connectivity; however, little is known regarding the spatiotemporal organization of brain networks in this population. We provide the first examination of resting-state neuromagnetic connectivity mapped in brain space in school age children born very preterm. Thirty-four subjects (age range 7–12 years old), consisting of 17 very preterm-born children and 17 full-term born children were included. Very preterm-born children exhibited global decreases in inter-regional synchrony in all analysed frequency ranges, from theta (4–7 Hz) to high gamma (80–150 Hz; p < 0.01, corrected). These reductions were expressed in spatially and frequency specific brain networks (p < 0.0005, corrected). Our results demonstrate that mapping connectivity with high spatiotemporal resolution offers new insights into altered organization of neurophysiological networks which may contribute to the cognitive difficulties in this vulnerable population.
Journal: NeuroImage: Clinical - Volume 9, 2015, Pages 376–384