کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3075438 1580962 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Combined effects of type 2 diabetes and hypertension associated with cortical thinning and impaired cerebrovascular reactivity relative to hypertension alone in older adults
ترجمه فارسی عنوان
اثرات ترکیبی دیابت نوع 2 و فشار خون بالا در ارتباط با نازک شدن قشر و واکنش پذیری مغز و اعصاب نسبت به افزایش فشار خون بالا در افراد مسن
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• CThk and CVR decrease in the presence of T2DM and HTN vs. HTN alone.
• Combined effects of T2DM and HTN are prominent in the right occipital areas.
• CVR impairment in HTN + T2DM extends to bilateral occipito-parietal areas.
• Executive function correlates with CThk but not CVR in this cohort.

ObjectiveType 2 diabetes mellitus is characterized by metabolic dysregulation in the form of hyperglycemia and insulin resistance and can have a profound impact on brain structure and vasculature. The primary aim of this study was to identify brain regions where the combined effects of type 2 diabetes and hypertension on brain health exceed those of hypertension alone. A secondary objective was to test whether vascular impairment and structural brain measures in this population are associated with cognitive function.Research design and methodsWe enrolled 18 diabetic participants with hypertension (HTN + T2DM, 7 women, 71.8 ± 5.6 years) and 22 participants with hypertension only (HTN, 12 women, 73.4 ± 6.2 years). Cerebrovascular reactivity (CVR) was assessed using blood oxygenation level dependent (BOLD) MRI during successive breath holds. Gray matter structure was evaluated using cortical thickness (CThk) measures estimated from T1-weighted images. Analyses of cognitive and blood data were also performed.ResultsCompared to HTN, HTN + T2DM had decreased CVR and CThk in a spatially overlapping region of the right occipital lobe (P < 0.025); CVR group differences were more expansive and included bilateral occipito-parietal areas (P < 0.025). Whereas CVR showed no significant associations with measures of cognitive function (P > 0.05), CThk in the right lingual gyrus ROI and regions resulting from a vertex-wise analysis (including posterior cingulate, precuneus, superior and middle frontal, and middle and inferior temporal regions (P < 0.025) were associated with executive function.ConclusionsIndividuals with T2DM and HTN showed decreased CVR and CThk compared to age-matched HTN controls. This study identifies brain regions that are impacted by the combined effects of comorbid T2DM and HTN conditions, with new evidence that the corresponding cortical thinning may contribute to cognitive decline.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 5, 2014, Pages 36–41
نویسندگان
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