کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3075450 1580962 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A tensor-based morphometry analysis of regional differences in brain volume in relation to prenatal alcohol exposure
ترجمه فارسی عنوان
تجزیه و تحلیل مورفومتری مبتنی بر تانسور اختلافات منطقه ای در حجم مغز در ارتباط با مشکالت الکل قبل از تولد
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• Tensor-based morphometry predicts brain volume reductions in fetal alcohol syndrome.
• Normalizing for brain size in FASD may mask regional differences in tissue volume.
• Patterns of volumetric change are pervasive, particularly in midline structures.
• Degree of prenatal alcohol exposure predicts pervasiveness of volumetric deficits.
• Pattern of volumetric change may be useful in identifying individuals with FASD.

Reductions in brain volumes represent a neurobiological signature of fetal alcohol spectrum disorders (FASD). Less clear is how regional brain tissue reductions differ after normalizing for brain size differences linked with FASD and whether these profiles can predict the degree of prenatal exposure to alcohol. To examine associations of regional brain tissue excesses/deficits with degree of prenatal alcohol exposure and diagnosis with and without correction for overall brain volume, tensor-based morphometry (TBM) methods were applied to structural imaging data from a well-characterized, demographically homogeneous sample of children diagnosed with FASD (n = 39, 9.6–11.0 years) and controls (n = 16, 9.5–11.0 years). Degree of prenatal alcohol exposure was significantly associated with regionally pervasive brain tissue reductions in: (1) the thalamus, midbrain, and ventromedial frontal lobe, (2) the superior cerebellum and inferior occipital lobe, (3) the dorsolateral frontal cortex, and (4) the precuneus and superior parietal lobule. When overall brain size was factored out of the analysis on a subject-by-subject basis, no regions showed significant associations with alcohol exposure. FASD diagnosis was associated with a similar deformation pattern, but few of the regions survived FDR correction. In data-driven independent component analyses (ICA) regional brain tissue deformations successfully distinguished individuals based on extent of prenatal alcohol exposure and to a lesser degree, diagnosis. The greater sensitivity of the continuous measure of alcohol exposure compared with the categorical diagnosis across diverse brain regions underscores the dose dependence of these effects. The ICA results illustrate that profiles of brain tissue alterations may be a useful indicator of prenatal alcohol exposure when reliable historical data are not available and facial features are not apparent.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 5, 2014, Pages 152–160
نویسندگان
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