کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3075597 1189022 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Egocentric spatial learning in schizophrenia investigated with functional magnetic resonance imaging
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Egocentric spatial learning in schizophrenia investigated with functional magnetic resonance imaging
چکیده انگلیسی

Psychotic symptoms in schizophrenia are related to disturbed self-recognition and to disturbed experience of agency. Possibly, these impairments contribute to first-person large-scale egocentric learning deficits. Sixteen inpatients with schizophrenia and 16 matched healthy comparison subjects underwent functional magnetic resonance imaging (fMRI) while finding their way in a virtual maze. The virtual maze presented a first-person view, lacked any topographical landmarks and afforded egocentric navigation strategies. The participants with schizophrenia showed impaired performance in the virtual maze when compared with controls, and showed a similar but weaker pattern of activity changes during egocentric learning when compared with controls. Especially the activity of task-relevant brain regions (precuneus and posterior cingulate and retrosplenial cortex) differed from that of controls across all trials of the task. Activity increase within the right-sided precuneus was related to worse virtual maze performance and to stronger positive symptoms in participants with schizophrenia. We suggest that psychotic symptoms in schizophrenia are related to aberrant neural activity within the precuneus. Possibly, first-person large-scale egocentric navigation and learning designs may be a feasible tool for the assessment and treatment of cognitive deficits related to self-recognition in patients with schizophrenia.


► Schizophrenia has been related to disturbed self-recognition and experience of agency.
► Schizophrenia patients show relative hypoactivation during egocentric maze learning.
► Positive symptoms are related to aberrant precuneus activity.
► Positive symptoms are related to impaired egocentric maze learning.
► Egocentric learning deficits may be indicative of disturbed experience of agency.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 1, Issue 1, 2012, Pages 153–163
نویسندگان
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