کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3078863 | 1189273 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Motor unit loss estimation by the multipoint incremental MUNE method in children with spinal muscular atrophy - A preliminary study
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب تکاملی
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چکیده انگلیسی
Quantitative EMG reflects denervation of muscles after lower motor neuron degeneration in spinal muscular atrophy (SMA) but does not reflect actual motor unit loss. The aim of our study was to assess the value of the multipoint incremental motor unit number estimation (MUNE) method in the modification by Shefner in estimating motor unit loss in SMA. The number of motor units, the mean amplitude of an average surface-detected single motor unit potential (SMUP), and the amplitude of compound motor action potentials (CMAP) were estimated in 14 children with SMA in the abductor pollicis brevis (ABP). Significant differences in MUNE values and SMUP and CMAP amplitude were found between the SMA and control groups (Pâ<â0.0001). MUNE values correlated with Hammersmith Functional Motor Scale (HFMS) scores (Pâ<â0.05). Increased SMUP amplitude values correlated with decreased HFMS scores (Pâ<â0.05). The study confirms that MUNE method in the modification by Shefner is a useful tool reflecting motor unit loss in SMA, and it is easy to perform and well tolerated. MUNE and SMUP amplitude seemed to be sensitive parameters reflecting motor dysfunction in SMA but a longitudinal study in a larger number of subjects is needed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuromuscular Disorders - Volume 25, Issue 3, March 2015, Pages 216-221
Journal: Neuromuscular Disorders - Volume 25, Issue 3, March 2015, Pages 216-221
نویسندگان
Malgorzata Gawel, Anna Kostera-Pruszczyk, Anna Lusakowska, Maria Jedrzejowska, Barbara Ryniewicz, Marta Lipowska, Damian Gawel, Anna Kaminska,