197th ENMC international workshop: Neuromuscular disorders of mitochondrial fusion and fission – OPA1 and MFN2 molecular mechanisms and therapeutic strategies: 26–28 April 2013, Naarden, The Netherlands

• Disturbed mitochondrial dynamics is an important cause of neuromuscular disorders.
• OPA1 and MFN2 are two important mediators of mitochondrial fusion.
• Pathogenic OPA1 mutations cause autosomal dominant optic atrophy (DOA).
• Pathogenic MFN2 mutations cause axonal Charcot–Marie–Tooth disease (CMT-2A).
• Treatment options are currently limited and remain mostly supportive.