کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3079447 1189304 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Charcot-Marie-Tooth 1A patients with low level of impairment have a higher energy cost of walking than healthy individuals
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
Charcot-Marie-Tooth 1A patients with low level of impairment have a higher energy cost of walking than healthy individuals
چکیده انگلیسی

The study aimed at quantifying the walking energy cost of a group of Charcot-Marie-Tooth 1A patients (CMT1A), with low severity of walking impairment, in comparison with healthy individuals. Oxygen uptake was measured in 8 patients (age-range 20–48 years; Barthel >90; Tinetti >20) and 8 healthy individuals, matched for age and gender, when walking on a circuit for 5-min at their self-selected speeds (“slow”, “comfortable” and “fast”). Both comfortable and fast speeds were lower in patients than in the control group (0.92 ± 0.16 vs 1.16 ± 0.22 and 1.27 ± 0.27 vs 1.61 ± 0.22 m s−1, respectively; P < 0.05), whereas walking energy cost per unit of distance was higher in patients than in the control group (P < 0.05) at both “comfortable” (2.27 ± 0.35 vs 1.92 ± 0.21 J kg−1 m−1) and “fast” speed (3.05 ± 0.35 vs 2.37 ± 0.42 J kg−1 m−1). CMT1A patients, therefore, choose to walk slower but with higher metabolic cost compared to healthy individuals, despite no clinically evident walking impairment, which is likely due to altered walking patterns.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuromuscular Disorders - Volume 21, Issue 1, January 2011, Pages 52–57
نویسندگان
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