کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3080093 1189327 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased fat mass and high incidence of overweight despite low body mass index in patients with spinal muscular atrophy
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
Increased fat mass and high incidence of overweight despite low body mass index in patients with spinal muscular atrophy
چکیده انگلیسی

Body composition is sparsely described in spinal muscular atrophy (SMA). Body (BMI, mass/height in m2), fat-free (FFMI, lean mass/height in m2) and fat (FMI, fat mass/height in m2) mass indexes were estimated in 25 children (aged 5–18) with SMA (2 type I, 13 type II, 10 type III) using dual-energy radiograph absorptiometry and anthropometric data referenced to gender and age-matched healthy children (NHANES III, New York Pediatric Rosetta Body Project). BMI was ⩾50th percentile in 11 (44%) and ⩾85th in 5 (20%). FFMI was reduced (p < 0.005) and FMI was increased (p < 0.005) in the overall study cohort. FMI was ⩾50th, ⩾85th and 95th percentiles in 19 (76%), 10 (40%) and 5 (20%) subjects, respectively. Using a receiver operator characteristic curve, BMI above 75th, 50th and 3rd percentiles maximized sensitivity and specificity for FMI ⩾95th, ⩾85th and ⩾50th percentiles, respectively. Children with SMA have reduced lean and increased fat mass compared to healthy children. Obesity is a potentially important modifiable source of morbidity in SMA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuromuscular Disorders - Volume 19, Issue 6, June 2009, Pages 391–396
نویسندگان
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