کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3080740 1189351 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduction of acethylcolinesterase activity in the brain of mdx mice
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
Reduction of acethylcolinesterase activity in the brain of mdx mice
چکیده انگلیسی
Lack of dystrophin in brain structures have been involved with impaired cognitive functions. Acethylcolinesterase (AChE) is implicated in many cognitive functions and probably plays important roles in neurodegenerative disorders. In the present study, we investigated AChE activity in the prefrontal cortex, hippocampus, striatum and cortex of mdx mice. To this aim, brain tissues from male dystrophic mdx and normal control mice were used. We observed that mdx mice display a reduction in AChE activity of 40-60% in all brain structures evaluated. In conclusion, dystrophin deficiency may be affecting AChE activity and contributing negatively, in part, to memory storage and restoring.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuromuscular Disorders - Volume 21, Issue 5, May 2011, Pages 359-362
نویسندگان
, , , , , , , , , ,