Stupor and Fast Activity on Electroencephalography in a Child Treated With Valproate

The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported. Stupor and fast activity have been related to the effects on γ-aminobutyric acid type A (GABAA) receptors mediated by endozepines or by exogenous drugs such as benzodiazepines or barbiturates. The action of valproate in GABA metabolism and in GABA neuronal networks could produce a similar result through a hyperrecruitment of GABA-mediated postsynaptic transmission.