کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3086632 1189873 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Coenzyme Q10 Absorption and Tolerance in Children With Down Syndrome: A Dose-Ranging Trial
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
Coenzyme Q10 Absorption and Tolerance in Children With Down Syndrome: A Dose-Ranging Trial
چکیده انگلیسی

Controlled studies of coenzyme Q10 dosing and tolerance have been reported in adults, but not in pediatric patients. This study compares low- and high-dose coenzyme Q10 (LiQ-NOL syrup) absorption and tolerance in children with Down syndrome. After a 1-month low-dose (1.0 mg/kg/day) run-in period, all participants received high-dose coenzyme Q10 (10.0 mg/kg/day) for two additional months (in randomized sequence as one daily dose or split into two daily doses). Chemistry profiles and complete blood counts were determined just before and at the study completion. Plasma coenzyme Q10 concentrations were determined initially and at each study visit. Parents reported adverse events and study drug evaluations using standardized forms. Most of the 16 children who completed this study tolerated high-dose coenzyme Q10 well. Uncooperative behavior resulted in premature withdrawal of two participants, and may have been treatment-related. Pre- and posttreatment laboratory test changes were considered to be clinically nonsignificant. Study results indicate that high-dose coenzyme Q10 (10 mg/kg/day) is well-absorbed and well-tolerated by most children with Down syndrome, and appears to provide plasma concentrations which are comparable to previous adult studies administering much higher coenzyme Q10 dosages.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pediatric Neurology - Volume 35, Issue 1, July 2006, Pages 30–37
نویسندگان
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