کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3103989 1191638 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Current concepts on burn wound conversion—A review of recent advances in understanding the secondary progressions of burns
ترجمه فارسی عنوان
مفاهیم کنونی در مورد تبدیل زخم سوختگی؛ بررسی پیشرفت های اخیر در درک پیشرفت ثانویه سوختگی
کلمات کلیدی
تبدیل زخم سوختگی؛ پیشرفت سوختگی؛ اتوفاژی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
چکیده انگلیسی


• We review recent progress in the pathophysiology of burn wound conversion.
• Halting burn progression will impact on the scar outcome and healing trajectory.
• Ischemia, inflammation, oxygen radicals are well accepted – autophagy is a new concept.

Burn wound conversion describes the process by which superficial partial thickness burns convert into deeper burns necessitating surgical intervention. Fully understanding and thus controlling this phenomenon continues to defy burn surgeons. However, potentially guiding burn wound progression so as to obviate the need for surgery while still bringing about healing with limited scarring is the major unmet challenge. Comprehending the pathophysiologic background contributing to deeper progression of these burns is an essential prerequisite to planning any intervention. In this study, a review of articles examining burn wound progression over the last five years was conducted to analyze trends in recent burn progression research, determine changes in understanding of the pathogenesis of burn conversion, and subsequently examine the direction for future research in developing therapies. The majority of recent research focuses on applying therapies from other disease processes to common underlying pathogenic mechanisms in burn conversion. While ischemia, inflammation, and free oxygen radicals continue to demonstrate a critical role in secondary necrosis, novel mechanisms such as autophagy have also been shown to contribute affect significantly burn progression significantly. Further research will have to determine whether multiple mechanisms should be targeted when developing clinical therapies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Burns - Volume 42, Issue 5, August 2016, Pages 1025–1035
نویسندگان
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