کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3122822 1583706 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association between funding, risk of bias, and outcome of randomised controlled trials in oral and maxillofacial surgery
ترجمه فارسی عنوان
ارتباط بین بودجه، خطر تعصب و نتیجه آزمایش های کنترل شده تصادفی در جراحی دهان و فک و صورت
کلمات کلیدی
خطر تقصیر، تقارن مالی آزمایش تصادفی کنترل شده، جراحی دهان و فک و صورت
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی

The influence of funding on the main outcome of a random control trial (RCT) is important, as it could potentially lead to bias towards industry, and results that are too optimistic. We investigated the association between funding, the published outcome, and the risk of bias in trials in oral and maxillofacial surgery (OMFS) published from January 2000 to May 2013 listed in PubMed. The methods used were scored using the risk of bias items given in a Delphi List. Sources of funding were recorded and categorised five ways: not funded, funded by industry, not funded by industry, supported by industry, and source of funds not clear. A total of 390 RCT met the inclusion criteria, and there was a correlation between funding and favourable main outcomes, although this was not significant. There was no correlation between the risk of bias and favourable results of the main outcome of a trial, or between the risk of bias and the reported source of funding in post-hoc analysis. We were unable to show a significant correlation between funding and a higher likelihood of a favourable result for the primary outcome in RCT in OMFS. We also failed to show a significant correlation between the risk of bias of a trial and its main outcome. In contrast, the source of funding proved to affect the risk of bias of a trial significantly, although not in post-hoc analysis. Funded trials were better organised, and so had a lower risk of bias.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: British Journal of Oral and Maxillofacial Surgery - Volume 54, Issue 1, January 2016, Pages 46–50
نویسندگان
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