کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3124743 1583753 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Acceleration of consolidation period by thrombin peptide 508 in tibial distraction osteogenesis in rats
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Acceleration of consolidation period by thrombin peptide 508 in tibial distraction osteogenesis in rats
چکیده انگلیسی

We aimed to find out whether a single local injection of two different doses of thrombin peptide 508 (TP508) could accelerate consolidation of bone in sites of tibial distraction osteogenesis in rats. Forty-eight adult male Sprague–Dawley rats were divided equally (n = 16 in each group) into controls (given saline alone), and two experimental groups, given injections of TP508 10 μg or 100 μg. The animals were killed on days 14 and 28 after distraction. Histomorphometric evaluation showed that the TP508 resulted in significantly larger areas of newly formed bone (p < 0.003 and p < 0.0001) than saline alone. At 2 weeks, more new bone had formed in the group given TP508 100 μg than in the group given 10 μg, but the difference was not significant (p = 0.8). However, the difference was significant at 4 weeks (p = 0.03). These findings suggest that a single injection of TP508 given at the end of the distraction period increased the degree of consolidation. The higher dose was more effective at the later time point.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: British Journal of Oral and Maxillofacial Surgery - Volume 48, Issue 8, December 2010, Pages 633–636
نویسندگان
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