کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3132910 | 1584157 | 2013 | 6 صفحه PDF | دانلود رایگان |
The purpose of this study was to evaluate the use of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) to identify extracapsular spread (ECS) with histologic correlations in oral squamous cell carcinoma (OSCC). The medical records of 80 patients who underwent of FDG PET/CT for OSCC before surgery were reviewed. ECS was present in 60% (24/40) dissected necks and in 55% (39/71) of dissected cervical levels. A significant difference was found between the maximum standardized uptake (SUVmax) values of cervical lymph nodes with ECS and without ECS (3.33 ± 1.91 vs. 1.12 ± 1.24, p < 0.001). When receiver operating characteristic (ROC) curve analysis and SUVmax values were used to detect ECS, the area under the ROC curve was 0.864 ± 0.045 (p < 0.001). At an optimal SUVmax cut-off value of 2.25 the sensitivity and specificity were 85% and 88%, respectively. The presence of ECS and a SUVmax > 2.25 had a significant adverse effect on 5-year disease specific survival. A SUVmax > 2.25 was found to be associated with a greater risk of cervical lymph node metastasis in OSCC.
Journal: International Journal of Oral and Maxillofacial Surgery - Volume 42, Issue 2, February 2013, Pages 158–163