کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3133302 1584181 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The utility of toluidine blue staining and brush cytology as adjuncts in clinical examination of suspicious oral mucosal lesions
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
The utility of toluidine blue staining and brush cytology as adjuncts in clinical examination of suspicious oral mucosal lesions
چکیده انگلیسی

The objective of this study was to investigate the utility of toluidine blue and brush cytology in patients with clinically detected oral mucosal lesions. Clinical examination of 35 patients was completed before toluidine blue application, oral brush cytology and scalpel biopsy. Lesions were photographed before and after stain application; followed by brush cytology. All findings were compared with histopathologic results. Severe dysplasia and carcinoma-in-situ were determined as ‘positive’; no dysplasia and mild to moderate dysplasia were defined as ‘negative’. The sensitivity, specificity, positive and negative predictive values of clinical examination and toluidine blue were the same: 0.923, 0.433, 0.414, and 0.929, respectively. Those of brush cytology were 0.923, 0.517, 0.462, and 0.938. The concordance of all methods was 30% for benign and 61% for malignant lesions. Adjuncts identified 92% of carcinoma-in-situ and squamous cell carcinoma as confirmed by histopathology, in contrast to clinical findings alone in which 62% of these lesions were identified (p = 0.046). In conclusion, adjunct diagnostic methods decreased the level of uncertainty for the diagnosis of oral malignancies and lichenoid dysplasias when applied as adjuncts to clinical examination.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Oral and Maxillofacial Surgery - Volume 40, Issue 2, February 2011, Pages 155–161
نویسندگان
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