Synchronous multicentric osteosarcoma involving mandible and maxillas

Synchronous multicentric osteosarcoma (SMO) is rare with fewer than 100 well-documented cases in the medical literature. SMO affecting the jaw is even rarer with only three cases involving the mandible having been reported. SMO in the maxilla has not been previously reported. The authors report the first case of SMO involving both mandible and maxilla in an 18-year-old girl. The clinical course, radiological and histological appearance of the lesion indicated it was an SMO rather than metastasis arising from a single osteosarcoma. This case could be regarded as powerful evidence to support the multicentric theory related to SMO.