Navigation-assisted localisation and resection of subclinical metastatic malignant melanoma of unknown primary based on 18-fluorodeoxyglcose positron emission tomography computed tomography fusion imaging

A technical application using a stereotactic navigation system with fusion images of [18F]-2-fluorodeoxyglucose (FDG) positron tomography and computed tomography (PET-CT) in the case of a metastatic melanoma of unknown primary site is described. A 50-year-old woman presented with a slow, growing level V neck lump which was cytologically proved to be a metastatic melanoma despite the absence of prior or existing history of skin malignancy. Whilst detailed physical examination failed to yield the site of the primary lesion, full body FDG-PET images isolated FDG-avid subclinical scalp lesions. Fused PET-CT data provided the navigation system with accurate localisation of the subclinical metastatic lesion. Histopathological examination of the navigation-guided resection specimen confirmed that the lesion was excised with acceptable margins. This case illustrates the feasibility of navigation-assisted resection of a subclinical malignant melanoma lesion and may have a role to play in the management of the melanoma of unknown primary.