Primary typical carcinoid tumour in the retromolar region with prominent squamous differentiation: a case report

Primary carcinoid tumours of the oral cavity are rare, with only one case of atypical carcinoid tumour reported in the literature. In this article, a case of primary typical carcinoid tumour in the retromolar region in a 46-year-old woman is described. Histologically, the tumour was characterized by submucosal proliferation of medium-sized monomorphous epithelioid cells with an organoid and nesting pattern of growth. Mitoses and necrosis were not found. Prominent squamous differentiation was present. Immunohistochemically, the tumour was diffuse positive for cytokeratin (CK) (AE1/AE3), CK7, p63, neurone-specific enolase, synaptophysin, and chromogranin. To the authors’ knowledge, this is the first report of primary typical carcinoid tumour in the oral cavity.