کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3133942 1584213 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Orthotopic bone formation in titanium fiber mesh loaded with platelet-rich plasma and placed in segmental defects
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Orthotopic bone formation in titanium fiber mesh loaded with platelet-rich plasma and placed in segmental defects
چکیده انگلیسی

The effect of platelet-rich plasma (PRP) on bone formation was investigated in a rabbit segmental radial defect model. The purpose of the study was to evaluate the bone inductive properties of PRP with titanium fiber mesh and autologous bone chips in a 15-mm rabbit radial defect model. Eighteen New Zealand white rabbits were divided into three groups: I, PRP with autologous bone (PRP-Ti-Bone); II, autologous bone (Ti-Bone); III, control group (Ti). The implants were placed in the radial defect for 12 weeks. After sacrifice, all specimens were harvested for histological, histomorphometrical and radiographic analysis. Histomorphometrical analysis showed that bone formation was higher in the implants with PRP (PRP-Ti-Bone: 37 ± 8%) than in those without PRP (Ti-bone: 25 ± 6% and Ti: 25 ± 5%) after 12 weeks of implantation. It was concluded that PRP has a stimulatory effect on bone formation in titanium fiber mesh filled with autologous bone graft in segmental bone defects. Titanium fiber mesh was also shown to be an excellent scaffold material for the application of autologous bone grafts with or without PRP.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Oral and Maxillofacial Surgery - Volume 37, Issue 6, June 2008, Pages 542–549
نویسندگان
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