کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3134298 1584234 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Calcitonin therapy in central giant cell granuloma of the jaw: a randomized double-blind placebo-controlled study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Calcitonin therapy in central giant cell granuloma of the jaw: a randomized double-blind placebo-controlled study
چکیده انگلیسی

The successful therapeutic use of calcitonin in patients with a central giant cell granuloma has been shown in several case reports. In a prospective, randomized, double-blinded, placebo-controlled clinical trial, 14 patients with a histologically confirmed central giant cell granuloma and normal calcium and parathyroid hormone serum levels were studied over 2 years. Patients were treated with intranasally administered salmon calcitonin (200 IU/day) or a placebo once a day. The placebo-controlled period was 3 months, after which all patients were treated with calcitonin for 1 year. Treatment response was assessed at the end of the placebo-controlled study phase (3 months), at the end of therapy (15 months’ timepoint with patients being on calcitonin treatment for either 12 or 15 months) and at 6 months’ follow-up. The χ2-test was used to compare the proportion of patients with a tumour reduction ≥10% of the pretreatment measurement between the 2 populations at the 3 timepoints: no differences were observed between the placebo group and the calcitonin group. At the 6-month follow-up timepoint, tumour volume had decreased by ≥10% in a total of 7 patients with a 37.9% (95% CI 31.3–44.5%) mean volume reduction in this subgroup. Complete remission was not observed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Oral and Maxillofacial Surgery - Volume 35, Issue 9, September 2006, Pages 791–795
نویسندگان
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