کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3134818 1584227 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The influence of recombinant human BMP-2 on bone–implant osseointegration: biomechanical testing and histomorphometric analysis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
The influence of recombinant human BMP-2 on bone–implant osseointegration: biomechanical testing and histomorphometric analysis
چکیده انگلیسی

The healing period for bone–implant osseointegration lasts 3–6 months or even longer. The aim of this study was to investigate whether osseointegration can be enhanced by the use of bone morphogenetic protein-2 (BMP-2). In the femurs of 8 Japanese white rabbits, 16 implants were applied with 1.0 mg recombinant human BMP-2 (rhBMP-2) as group A, and the other 16 implants without rhBMP-2 as group B. Calcein green 20 mg/kg and alizarin red 20 mg/kg were injected 4 and 8 weeks after implantation, respectively. At 12 weeks, the animals were killed. In 16 implant–bone blocks, binding strength was measured by pull-out test, and the extracted implants were observed under a scanning electronic microscope. The other blocks were analysed for percentage of marked bone adjacent to the implant surface by confocal laser scanning microscope. The pull-out strengths of group A were greater than that of group B (P < 0.05). Scanning electronic microscopy (SEM) showed more calcified substances on the surface of the implants of group A than B. There was more marked bone around group A than B implants at 4 weeks (P < 0.05) and 8 weeks (P < 0.05). rhBMP-2 improves the quantity and quality of implant–bone osseointegration. Biomechanical testing and histomorphometric analysis are reliable methods to use in researching the implant–bone interface.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Oral and Maxillofacial Surgery - Volume 36, Issue 4, April 2007, Pages 345–349
نویسندگان
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