کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3135036 | 1584235 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Up-regulation of a serine-threonine kinase proto-oncogene Pim-1 in oral squamous cell carcinoma
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Up-regulation of a serine-threonine kinase proto-oncogene Pim-1 in oral squamous cell carcinoma Up-regulation of a serine-threonine kinase proto-oncogene Pim-1 in oral squamous cell carcinoma](/preview/png/3135036.png)
چکیده انگلیسی
The Pim-1 proto-oncogene, encoding a serine-threonine kinase, has been found to play an important role in regulating apoptosis, differentiation, proliferation and tumourigenesis. The present study was conducted to assess the importance of Pim-1 in oral tumourigenesis in vivo. Reverse transcriptase-polymerase chain reaction and immunohistochemistry were used to study the expression of Pim-1 in oral squamous cell carcinoma (OSCC) and non-cancerous match tissue (NCMT) sampled from the periphery of the tumours. Pim-1 mRNA expression in OSCC was significantly higher than that in NCMT in 36 tissue pairs (1.33 ± 0.41 versus 0.97 ± 0.29, P = 0.03). The percentage of OSCCs exhibiting strong cytoplasmic Pim-1 immunoreactivity was significantly higher than that of NCMT (60% versus 19%, P = 0.007). Pim-1 immunoreactivity is higher in the more differentiated components of a tumour. In around 10% of OSCC cases, Pim-1 immunoreactivity was found in the nucleus as well. These results show novel findings of the up-regulation of Pim-1 expression from NCMT to OSCC. The pathogenetic role of Pim-1 expression in oral tumourigenesis deserves further investigation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Oral and Maxillofacial Surgery - Volume 35, Issue 8, August 2006, Pages 740-745
Journal: International Journal of Oral and Maxillofacial Surgery - Volume 35, Issue 8, August 2006, Pages 740-745
نویسندگان
W.-F. Chiang, C.-Y. Yen, C.-N. Lin, G.-A. Liaw, C.-T. Chiu, Y.-J. Hsia, S.-Y. Liu,