Curcumin induced up-regulation of Myelin basic protein (MBP) ameliorates sodium arsenite induced neurotoxicity in developing rat cerebellum

The up-regulation of cerebellar MBP expression together with improved exploratory behavior of animals subjected to combined exposure to Curcumin and arsenic (iAs) provides the experimental evidence for mechanistic role of Curcumin in ameliorating NaAsO2 induced neurotoxicity, probably based on the essential properties of Curcumin such as scavenging free radicals and chelation of arsenic.