Cytidine-Phosphate-Guanosine Oligonucleotides Induce Interleukin-8 Production through Activation of TLR9, MyD88, NF-κB, and ERK Pathways in Odontoblast Cells

These data demonstrate that CpG ODN-induced IL-8 expression was mediated through TLR9, MyD88, NF-κB, and ERK pathways in MDPC-23 cells and suggest a possible role for the CpG DNA-mediated immune response in odontoblasts with involvement of TLR9, MyD88, and ERK pathways in this process.