کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3147529 1197368 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bleaching Agents Increase Metalloproteinases-mediated Collagen Degradation in Dentin
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Bleaching Agents Increase Metalloproteinases-mediated Collagen Degradation in Dentin
چکیده انگلیسی

IntroductionTooth bleaching is based on hydrogen peroxide application. The Objective of this study was to determine whether dental bleaching agents affect metalloproteinases-mediated dentin collagen degradation.MethodsHuman dentin specimens were subjected to different treatments: (1) untreated dentin; (2) demineralization by 37% phosphoric acid (PA); (3) demineralization by 37% PA, followed by application of Single Bond (SB); (4) 2 immersions of 7 days each in a nonvital bleaching agent, followed by PA; (5) 2 immersions of 7 days each in nonvital bleaching, followed by PA and SB application; (6) 3 immersions by using in-office bleaching gel for 20 minutes; (7) 3 immersions by using in-office bleaching gel for 20 minutes plus activation with a light source; and (8) immersion in home bleaching gel for 8 hours per day during 3 weeks. Specimens were stored in artificial saliva. C-terminal telopeptide determinations (radioimmunoassay) were performed after 24 hours, 1 week, and 4 weeks.ResultsBleaching agents increased collagen degradation, but C-terminal telopeptide of type I collagen (ICTP) values were higher when dentin was PA-demineralized. Nonvital bleaching plus PA promoted the highest collagenolytic activity, which was reduced after SB infiltration. Halogen light application did not influence ICTP values. At 24 hours, home bleaching exhibited high collagenolytic activity, which decreased up to 4 weeks. After 4 weeks of storage, all bleaching procedures showed similar values of collagen degradation, which were not different from those of PA-demineralized and resin-infiltrated dentin.ConclusionsAll tested bleaching agents increase matrix metalloproteinases-mediated collagen degradation in dentin. This effect was not completely reverted after 4 weeks. Home bleaching induced the highest collagen degradation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Endodontics - Volume 37, Issue 12, December 2011, Pages 1668–1672
نویسندگان
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