کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3149934 1197487 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Effect of Sodium Hypochlorite and Chlorhexidine as Irrigant Solutions for Root Canal Disinfection: A Systematic Review of Clinical Trials
ترجمه فارسی عنوان
اثر هیپوکلریت سدیم و کلرهگزیدین به عنوان راه حل های آبیاری برای ضد عفونی کانال ریشه: بررسی سیستماتیک محاکمات بالینی
کلمات کلیدی
کلرهگزیدین، کارازمایی بالینی، اندودونتیک، هیپوکلریت سدیم
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی


• Of the 172 potential articles, only 4 randomized clinical trials and 1 nonrandomized clinical trial were included in this systematic review.
• The laboratory methods used to evaluate root canal disinfection were heterogeneous among studies (culture techniques and molecular methods).
• The 5 studies compared sodium hypochlorite and chlorhexidine by collecting samples from the root canal before and after the protocol treatments.
• Randomization was conducted in 4 of the 5 studies.
• There was a lack of agreement between the findings of the selected studies.

IntroductionThis systematic review aimed to compare the effectiveness of sodium hypochlorite and chlorhexidine for root canal disinfection during root canal therapy.MethodsA literature search for clinical trials was made on the PubMed (MEDLINE), Web of Knowledge, SCOPUS, and Science Direct databases and in the reference lists of the identified articles up to January 2015. Quality assessment of the selected studies was performed according to the Consolidated Standards of Reporting Trials statement.ResultsOne clinical trial and 4 randomized clinical trials were selected from the 172 articles initially identified. There was heterogeneity in the laboratory methods used to assess the root canal disinfection as well as in the concentrations of the irrigants used. Therefore, meta-analysis was not performed. Two studies reported effective and similar reductions in bacterial levels for both irrigants. Sodium hypochlorite was more effective than chlorhexidine in reducing microorganisms in 1 study, and another reported opposite findings. Both root irrigants were ineffective in eliminating endotoxins from necrotic pulp root canals in 1 study. Trial design and information regarding randomization procedures were not clearly described in the clinical trials. No study compared laboratory results with clinical outcomes.ConclusionsThe available evidence on this topic is scarce, and the findings of studies were not consistent. Additional randomized clinical trials using clinical outcomes to compare the use of sodium hypochlorite and chlorhexidine during root canal therapy are needed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Endodontics - Volume 42, Issue 4, April 2016, Pages 527–532
نویسندگان
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