Surgical resection or additional radiotherapy after superselective intra-arterial chemotherapy (docetaxel, cisplatin, and 5-fluorouracil) using the Seldinger technique and concurrent chemoradiotherapy for T3 or T4 oral squamous cell carcinoma

ObjectiveWe report the outcomes of 18 patients with first-onset or previously untreated T3 or T4 oral squamous cell carcinoma (SCC) who received concurrent rapid arterial injection of cisplatin and docetaxel via the femoral artery and intravenous 5-fluorouracil with irradiation (40 Gy), followed by salvage surgery or additional radiation (20 Gy).MethodThey visited our department June 2007–October 2012.ResultsFour (22%) patients achieved complete response (CR). After radiotherapy, the patients with an additional 20 Gy, primary site samples underwent a biopsy. The histopathological score was CR in all 4 patients. Thirteen (72%) patients and 1 (6%) patient achieved a partial response (PR) and no change (NC), respectively. They underwent surgery. As the extent of surgical resection was reset after treatment, it reduced in most of the patients. Seven (50%) patients underwent neck surgery and three patients underwent reconstructive surgery using the pectoralis major myocutaneous flap.ConclusionThe 3-year survival rate and 3-year local control rate were 94.4% and 100%, respectively.