کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3162121 1198621 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum Serotonin Abnormality in Depression
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Serum Serotonin Abnormality in Depression
چکیده انگلیسی

BackgroundSerotonin plays an important role in treatment of depression. We evaluated the clinical correlates of plasma serotonin levels in depressed patients before and after treatment.MethodsStudy sample comprised of 40 patients diagnosed on ICD-10 diagnostic criteria, and an equal number of healthy matched controls. Subjects were evaluated on Beck's Depression Inventory (BDI) and Suicide Ideation Scale (SIS), before and after the treatment. Blood samples were collected from all the cases and controls before starting the antidepressant medication with selective serotonin reuptake inhibitors (SSRI's). Serum serotonin levels were measured before and after treatment.ResultSignificant differences in scores before and after the intervention on BDI, SIS and serotonin levels of cases and controls (p<.000) were noted. Correlation between the serum serotonin levels before and after the treatment, and between the rating scales did not reveal significant association (p > 0.05). Patients with suicidal intentions had lower levels of serotonin. The scores changed after intervention.ConclusionTreatment with SSRI's had shown significant changes in clinical conditions. However these changes did not relate significantly with serum serotonin levels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Journal Armed Forces India - Volume 65, Issue 2, April 2009, Pages 108–112
نویسندگان
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