کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3166492 1199116 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Osteoradionecrosis following treatment for head and neck cancer and the effect of radiotherapy dosimetry: the Guy's and St Thomas' Head and Neck Cancer Unit experience
ترجمه فارسی عنوان
استئوآرادیونکروز پس از درمان سرطان سر و گردن و اثر دوزیمتری رادیوتراپی: تجربه سرطان سر و گردن گیت و سنت توماس
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی

ObjectivesTo analyze clinical features, dosimetric parameters, and outcomes of osteoradionecrosis (ORN).Study DesignThirty-six patients with ORN who had been previously treated with radiotherapy (RT) were retrospectively identified between January 2009 and April 2014. ORN volumes were contoured on planning computed tomography (CT) scans. Near maximum dose (D2%), minimum dose (Dmin), mean dose (Dmean), and percentage of bone volume receiving 50 Gy (V50) were examined. Clinical and dosimetric variables were considered to compare ORN resolution versus ORN persistence.ResultsMedian interval time from end of RT to development of ORN was 6 months. Of the ORN cases, 61% were located in the mandible. Dmean to affected bone was 57.6 Gy, and 44% had a D2% 65 Gy or greater. Smoking was associated with ORN persistence on univariate analysis, but no factors were found to impact ORN resolution or progression on logistic regression.ConclusionsPrevention strategies for ORN development should be prioritized. Dose-volume parameters could have a role in preventing ORN.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Volume 122, Issue 1, July 2016, Pages 28–34
نویسندگان
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