کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3194701 | 1201404 | 2012 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bullous pemphigoid: From the clinic to the bench
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
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چکیده انگلیسی
Bullous pemphigoid (BP) constitutes the most frequent autoimmune subepidermal blistering disease. It is associated with autoantibodies directed against the BP antigens 180 (BP180, BPAG2) and BP230 (BPAG1-e). The pathogenicity of anti-BP180 antibodies has been convincingly demonstrated in animal models. The clinical features of BP are extremely polymorphous. The diagnosis of BP critically relies on immunopathologic findings. The recent development of novel enzyme-linked immunosorbent assays has allowed the detection of circulating autoantibodies with relatively high sensitivity and specificity. Although potent topical steroids have emerged in the past decade as first-line treatment of BP, management of the disease may be challenging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinics in Dermatology - Volume 30, Issue 1, January–February 2012, Pages 3–16
Journal: Clinics in Dermatology - Volume 30, Issue 1, January–February 2012, Pages 3–16
نویسندگان
Giovanni Di Zenzo, Rocco della Torre, Giovanna Zambruno, Luca Borradori,