کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3195002 | 1201419 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chemokines and other mediators as therapeutic targets in psoriasis vulgaris
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
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چکیده انگلیسی
In recent years, our knowledge of the immunopathogenesis of chronic inflammatory skin diseases has increased significantly. Accumulating evidence indicates that the complex interaction of structural cells, in particular keratinocytes and endothelial cells, with skin-infiltrating leukocytes is key to our understanding of psoriasis. The recruitment of pathogenic leukocyte subsets into the skin represents a prerequisite for the initiation and maintenance of psoriasis vulgaris and is mediated by a complex chemokine and cytokine network. Results of recent studies associating cytokines and chemokines with a psoriatic phenotype are outlined herein, and their role as therapeutic targets in psoriasis is discussed in detail.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinics in Dermatology - Volume 26, Issue 5, September–October 2008, Pages 539–545
Journal: Clinics in Dermatology - Volume 26, Issue 5, September–October 2008, Pages 539–545
نویسندگان
Bernhard Homey, Stephan Meller,