French referral center management of Stevens–Johnson syndrome/toxic epidermal necrolysis

Drug-induced adverse reactions represent major health problems, with the skin being one of the most common targets. Approximately 2% of all drug-induced skin reactions are considered serious. Stevens–Johnson syndrome/toxic epidermal necrolysis corresponds to rare and acute life-threatening mucocutaneous reactions characterized by extensive necrosis and epidermal detachment. This review focuses on the management of these severe cutaneous reactions in the French Referral Center for Toxic Bullous Diseases. Early referral to a specialized unit, early diagnosis of severe cutaneous adverse reactions, prompt withdrawal of the culprit drug, improved symptomatic management, and specific dermatological care have contributed to better survival in the past 10 years and also has limited sequelae.