کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3212662 1203190 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel mechanism for improvement of dry skin by dietary milk phospholipids: Effect on epidermal covalently bound ceramides and skin inflammation in hairless mice
ترجمه فارسی عنوان
یک مکانیسم جدید برای بهبود پوست خشک با استفاده از فسفولیپید های شیرین: اثر بر روی سرامید های متخلخل کووالانسی اپیدرمی و التهاب پوست در موش های بدون مو
کلمات کلیدی
فسفولیپید شیر عملکرد مانع پوست، سرامید های متخلخل به طور موقت، التهاب پوست، موش های بدون مو
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
چکیده انگلیسی


• Dietary milk phospholipids improved dry skin conditions in hairless mice.
• Milk phospholipids attenuated a decrease in epidermal protein-bound ω-hydroxy ceramide levels.
• Milk phospholipids lowered levels of skin and serum markers of inflammation.

BackgroundDietary milk phospholipids (MPLs) increase hydration of the stratum corneum and reduced transepidermal water loss (TEWL) in hairless mice fed a standard diet. However, the mechanism by which MPLs improve skin barrier functions has yet to be established.ObjectiveThis study was designed to examine the mechanism by which MPLs may affect covalently bound ceramides and markers of skin inflammation and improve the skin barrier defect in hairless mice fed a magnesium-deficient (HR-AD) diet.MethodsFour-week-old female hairless mice were randomized into four groups (n = 10/group), and fed a standard (control) diet, the HR-AD diet, the HR-AD diet supplemented with either 7.0 g/kg MPLs (low [L]-MPL) or 41.0 g/kg MPLs (high [H]-MPL).ResultsDietary MPLs improved the dry skin condition of hairless mice fed the HR-AD diet. MPLs significantly increased the percentage of covalently bound ω-hydroxy ceramides in the epidermis, and significantly decreased both thymus and activation-regulated chemokine (TARC) mRNA and thymic stromal lymphopoietin (TSLP) mRNA levels in skin, compared with the HR-AD diet. Furthermore, the MPL diets significantly decreased serum concentrations of immunoglobulin-E, TARC, TSLP, and soluble P-selectin versus the HR-AD diet.ConclusionOur study showed for the first time that dietary MPLs may modulate epidermal covalently bound ceramides associated with formation of lamellar structures and suppress skin inflammation, resulting in improved skin barrier function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dermatological Science - Volume 78, Issue 3, June 2015, Pages 224–231
نویسندگان
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