کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3214339 1203284 2007 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discriminating roles of desmosomal cadherins: Beyond desmosomal adhesion
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Discriminating roles of desmosomal cadherins: Beyond desmosomal adhesion
چکیده انگلیسی

SummaryThe desmosomal cadherins, which include desmogleins and desmocollins, are Ca2+-dependent adhesion molecules that cooperate to make up the adhesive core of intercellular junctions known as desmosomes. The roles of desmosomal cadherins in epidermal integrity and as targets in human cutaneous disease have been well established. However, the molecular basis of these disorders is still poorly understood, due in part to a lack of fundamental knowledge about the organization of the adhesive interface and molecular machinery that dictates the proper presentation of desmogleins and desmocollins on the cell surface. Further, the diversity of the desmosomal cadherin family, and their individualized expression patterns within complex tissues, suggests that these adhesion molecules may have differentiation-specific functions that transcend their roles in intercellular adhesion. Here we will review the most recent data from our own group and others that are beginning to unveil the diverse properties and functions of this complex family of adhesion molecules.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dermatological Science - Volume 45, Issue 1, January 2007, Pages 7–21
نویسندگان
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