کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3214733 1587827 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of oxidative stress in oral lichen planus using malonaldehyde: A systematic review
ترجمه فارسی عنوان
بررسی استرس اکسیداتیو در لیگن پلان دهانی با استفاده از مالونالدئید: بررسی سیستماتیک
کلمات کلیدی
لیگن پلان دهانی، پیش شرطی، مالونالدئید، استرس اکسیداتیو
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
چکیده انگلیسی

BackgroundOral lichen planus is a chronic, mucocutaneous, inflammatory disease, with an unknown aetiology. Reactive Oxygen Species and oxidative damage to the tissues might be the cause. Malonaldehyde, a low molecular weight end product of lipid peroxidation reaction is a suitable biomarker of endogenous DNA damage.AimsTo analyse the existing literature on the “evaluation of oxidative stress in oral lichen planus using malonaldehyde as a biomarker”.MethodsElectronic search of scientific papers was carried out in Pubmed (MeSH), Science direct and Cochrane databases using specific keywords. Eight articles were finally selected that formed the base for this review.ResultsThe findings from the present review demonstrate that oxidative stress and consequently, elevated levels of malonaldehyde compared to controls, plays a role in the pathophysiology of oral lichen planus. In the eight relevant studies, estimation of the malonaldehyde in serum, saliva and tissue samples was done and its levels were found to be significantly higher than controls.ConclusionThis review reveals only 8 studies that demonstrate the elevated oxidative stress levels in oral lichen planus using malonaldehyde as a biomarker. Therefore, further studies need to be performed which would estimate the levels of MDA in serum, saliva and tissue samples of the same group of patients with oral lichen planus, so as to draw definitive conclusions and significant correlation between the MDA levels from the three samples.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dermatology & Dermatologic Surgery - Volume 18, Issues 1–2, January–July 2014, Pages 2–7
نویسندگان
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