کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3235018 1205435 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Botulinum toxin in Urology
ترجمه فارسی عنوان
سم بوتولینوم در اورولوژی
کلمات کلیدی
سم بوتولینوم؛ بیش فعالی مولکولی؛ مثانه بیش فعال؛ سندرم درد مثانه؛ اسفنکتر مجاری ادرار دای سینرژیک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب اورژانس
چکیده انگلیسی

IntroductionBotulinum toxin is a neurotoxin produced by Clostridium botulinum species of bacteria. This powerful toxin, which is the most poisonous substance known to mankind, has been used in highly dilute concentrations in urology. This review examines the various applications of botulinum toxin sub-type A (BTA) in the field of Urology.Material and methodsRecent literature with respect to the use of BTA in Urology was examined with specific reference to clinical applications.ResultsIntradetrusor injection of BTA has a wide and expanding role in Urology. Intradetrusor BTA injections lead to a significant increase in cystometric capacity and reduction in detrusor pressure in patients with neurogenic detrusor overactivity. In patients with idiopathic detrusor overactivity, there is significant reduction in urgency and frequency. There is also evidence to support the use of BTA in overactive bladder without detrusor overactivity, bladder pain syndrome, detrusor sphincter dyssynergia and dysfunctional voiding. Initial studies support the continued investigational use of intravesical catheter instillation of liposomal BTA. Evidence with regard to benign prostatic hyperplasia is conflicting and this treatment is not recommended for regular clinical use.ConclusionsThere is good quality evidence to support the use of intradetrusor BTA in patients with detrusor overactivity both neurogenic and idiopathic as well as in overactive bladder and bladder pain syndrome. The evidence with regards to detrusor sphincter dyssynergia, dysfunctional voiding and benign prostatic hyperplasia is less robust. Liposomal BTA delivery may present an attractive future option in Urological disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Apollo Medicine - Volume 11, Issue 4, December 2014, Pages 272–276
نویسندگان
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