کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3235384 1205451 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Guidelines for the management of relapsed acute lymphoblastic leukemia in childhood
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب اورژانس
پیش نمایش صفحه اول مقاله
Guidelines for the management of relapsed acute lymphoblastic leukemia in childhood
چکیده انگلیسی

Considerable progress has been made in the treatment of newly diagnosed childhood acute lymphoblastic leukemia. With the use of intensive, risk-stratified multiagent chemotherapeutic protocols, over 80% of patients can hope to be long-term survivors. However, despite optimal treatment, about 20% of patients relapse. The treatment of these children poses a major challenge. The prognosis of these patients depends on a number of factors including time since diagnosis, the site of relapse and immunophenotype. The choice of postinduction therapy depends on these prognostic factors. Considerable work has been done to identify the subgroups of relapsed patients whose outcomes are significantly altered by allogeneic bone marrow transplant. In our scenario, the limited availability of allogeneic bone marrow transplant due to a host of factors renders the management of these children even more challenging.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Apollo Medicine - Volume 8, Issue 4, December 2011, Pages 297-301