کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3235437 | 1205456 | 2011 | 4 صفحه PDF | دانلود رایگان |

Stem cell therapy has been one of the most exciting therapeutic modality to emerge in cardiology in the last decade. However excellent results in animal models has not been translated to clinical scenario. The potential cells include embryonic stem cells, adult stem cells and induced pluripotent stem cells. The proposed mechanisms of action include attenuation of the remodeling process, angiogenesis / arteriogenesis, paracrine effects and enhancement of repair by resident cardiac stem cells. Transcoronary approach following PCI and direct epicardial injections during CABG surgery are the preferred mode of drug delivery. Multiple clinical trials completed few years back did not show the hoped for clinical improvement. However the recent studies on fat derived stem cells appear promising. A pilot study using autologous peripheral blood derived stem cell therapy in patients with recent MI and undergoing CABG is ongoing at the Apollo Hospital Chennai.
Journal: Apollo Medicine - Volume 8, Issue 3, September 2011, Pages 191-194