Evaluation of Saraca indica for the management of dexamethasone-induced osteoporosis

ObjectiveThe aim of present study is to evaluate the effect of Saraca indica extract for the management of dexamethasone-induced osteoporosis in rats.MethodsFemale Wister rats were used for the investigation of antiosteoporotic activity of S. indica extract at the dose of 200 mg/kg/day, orally and various parameters such as alkaline phosphatase estimation, bone density, bone biomechanical strength, and ash value of bone were determined in dexamethasone-induced osteoporosis.ResultsAlkaline phosphatase level in the blood serum and ash value of the bone was found to be significant (p < 0.05) in the extract group as compared to the osteoporotic group while bone density and bone biomechanical strength of the femur bone of the extract group was found to be more than the osteoporotic group.ConclusionSaraca indica extract showed positive results in bone density, percentage ash value and biomechanical strength of rats.