کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3249519 1589158 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diagnosis and Management of Hereditary Angioedema: An Emergency Medicine Perspective
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب اورژانس
پیش نمایش صفحه اول مقاله
Diagnosis and Management of Hereditary Angioedema: An Emergency Medicine Perspective
چکیده انگلیسی

BackgroundHereditary angioedema (HAE) is a rare and often debilitating condition associated with substantial morbidity and mortality in the absence of appropriate intervention. An underlying deficiency in functional C1-inhibitor (C1-INH) protein induces a vulnerability to unchecked activation of the complement, contact, and coagulation/fibrinolytic systems. The clinical consequence is a pattern of recurring attacks of non-pitting, non-pruritic edema, the urgency of which varies by the affected site. Laryngeal edema can escalate rapidly to asphyxiation, and severe cases of abdominal swelling can lead to hypovolemic shock.ObjectivesThis report reviews the emergency diagnosis and treatment of hereditary angioedema and the impact of recently introduced treatments on treatment in the United States.DiscussionUntil recently, emergency physicians in the United States were hindered by the lack of rapidly effective treatment options for HAE attacks. In this article, general clinical and laboratory diagnostic procedures are reviewed against the backdrop of two case studies: one patient presenting with a known history of HAE and one with previously undiagnosed HAE. In many countries outside the United States, plasma-derived C1-INH concentrate has for decades been the first-line treatment for acute attacks. The end of 2009 ushered in a new era in the pharmacologic management of HAE attacks in the United States with the approval of two new treatment options for acute treatment: a plasma-derived C1-INH concentrate and a kallikrein inhibitor.ConclusionWith access to targeted and effective treatments, emergency physicians are now better equipped for successful and rapid intervention in urgent HAE cases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Emergency Medicine - Volume 43, Issue 2, August 2012, Pages 391–400
نویسندگان
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