کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3258958 1407310 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: A randomized, double-blind, placebo-controlled trial
ترجمه فارسی عنوان
اثر مکمل های پروبیوتیک بر روی پروفیل های کنترل و چربی قند خون در دیابت حاملگی: آزمایش دو سو کور، کنترل شده با پلاسبو تصادفی
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

BackgroundTo our knowledge, data on the effects of probiotic supplementation on glycaemic control and lipid concentrations in patients with gestational diabetes mellitus (GDM) are scarce.AimThe aim of the present study was to determine the effects of probiotic supplementation on glycaemic control and lipid profiles in GDM patients.MethodsSixty pregnant women with GDM, primigravida and aged 18–40 years, were divided into two groups to receive either probiotic capsules (n = 30) or a matching placebo (n = 30) in this randomized double-blind, placebo-controlled trial. The patients in the probiotic group took a daily capsule that contained three viable freeze-dried strains: Lactobacillus acidophilus (2 × 109 CFU/g), L. casei (2 × 109 CFU/g) and Bifidobacterium bifidum (2 × 109 CFU/g) for 6 weeks. The placebo group took capsules filled with cellulose for the same time period. Fasting blood samples were taken at the beginning and end of the study to quantify the relevant markers.ResultsAfter 6 weeks of intervention, probiotic supplementation vs a placebo resulted in significant decreases in fasting plasma glucose (−9.2 ± 9.2 mg/dL vs +1.1 ± 12.2 mg/dL, P < 0.001), serum insulin levels (−0.8 ± 3.1 μIU/mL vs +4.5 ± 10.6 μIU/mL, P = 0.01), homoeostasis model assessment (HOMA) for insulin resistance (−0.4 ± 0.9 vs +1.1 ± 2.5, P = 0.003) and HOMA for β-cell function (+1.1 ± 9.8 vs +18.0 ± 42.5, P = 0.03), and a significant increase in the quantitative insulin sensitivity check index (+0.007 ± 0.01 vs −0.01 ± 0.02, P = 0.007). In addition, significant decreases in serum triglycerides (−1.6 ± 59.4 mg/dL vs +27.1 ± 37.9 mg/dL, P = 0.03) and VLDL cholesterol concentrations (−0.3 ± 11.9 mg/dL vs +5.4 ± 7.6 mg/dL, P = 0.03) were seen following supplementation with the probiotics compared with the placebo. However, no significant changes in other lipid profiles were seen with the intervention.ConclusionOverall, the results of our study have demonstrated that taking probiotic supplements for 6 weeks in patients with GDM had beneficial effects on glycaemic control, triglycerides and VLDL cholesterol concentrations, although there was no effect on other lipid profiles.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes & Metabolism - Volume 42, Issue 4, September 2016, Pages 234–241
نویسندگان
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