کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3261635 1207701 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Faecal calprotectin assay after induction with anti-Tumour Necrosis Factor α agents in inflammatory bowel disease: Prediction of clinical response and mucosal healing at one year
ترجمه فارسی عنوان
بررسی اثرات کالپروتکتین فکاس پس از القاء با عوامل ضد عامل تخریب کننده تومور در بیماری های التهابی روده: پیش بینی واکنش های بالینی و بهبودی مخاطی در یک سال
کلمات کلیدی
عامل تخریب تومور α، فاکال کال پروتکتین، بیماری روده التهابی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

BackgroundFaecal calprotectin levels correlate with inflammation in inflammatory bowel disease. We evaluated the role of faecal calprotectin after anti-Tumour Necrosis Factor α induction in inflammatory bowel disease patients to predict therapeutic effect at one year.MethodsFaecal calprotectin levels were measured in stools of 63 patients before and after induction of anti-Tumour Necrosis Factor α therapy. Clinical activity, measured by clinical indices, was assessed before and after biologic treatment. Clinical responders after induction were included in the study and colonoscopy was performed before and after one year of treatment to assess mucosal healing.Results63 patients (44 Crohn's disease, 19 ulcerative colitis) were prospectively included (41.2% males, mean age at diagnosis 33 years). A sustained clinical response during the first year was observed in 57% of patients; median faecal calprotectin was 106 μg/g after induction versus 308 μg/g pre-induction (p < 0.0001). Post-induction faecal calprotectin was significantly lower in responders versus non-responders (p = 0.0002). Post-induction faecal calprotectin had 83% sensitivity and 74% specificity (cut-off ≤168 μg/g) for predicting a sustained clinical response at one year (p = 0.0001); also, sensitivity was 79% and specificity 57% (cut-off ≤121 μg/g) for predicting mucosal healing (p = 0.0001).ConclusionsIn inflammatory bowel disease faecal calprotectin assay after anti-Tumour Necrosis Factor α induction can be used as a marker to predict sustained clinical response and mucosal healing at one year.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 46, Issue 11, November 2014, Pages 974–979
نویسندگان
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